Popular for: arthritis & joint pains and inflammatory conditions, as well as brain fog and cognitive health, thanks to Longvida’s unique ability to cross the blood-brain barrier and exert its antioxidant effects neurologically.
Curcumin is a polyphenol obtained from turmeric, used for centuries in Chinese and Ayurvedic medicine as a treatment for inflammatory conditions, well known for supporting joint pain. Curcumin is the most potent of the three main curcuminoids found in turmeric and is directly responsible for the wide-ranging health benefits attributed to this characteristically yellow spice.
Despite its properties as an anti-inflammatory, antimicrobial and antioxidant, curcumin has poor bioavailability with a half-life of only a few minutes, so obtaining the desired benefits from a standard curcumin supplement is challenging. It’s estimated that less than 1% of standard curcumin is absorbed, and most of this is metabolised rapidly by gut enzymes or liver detoxification pathways, processes that prime it for efficient elimination by the kidneys, meaning that very little is retained in the circulation. As a result, most supplements offer very limited potential for providing benefits.
Several ways to enhance curcumin’s bioavailability do exist – piperine being one of the most widely known – but there are drawbacks to some of these delivery systems. Although it does enhance bioavailability, piperine does so by suppressing a key liver detoxification process called glucuronidation. The trouble with suppressing glucuronidation is that it plays a major role in how the body eliminates environmental toxins, hormones and medication. Stopping this pathway is not optimal, especially when there are better ways to enhance bioavailability. Importantly, piperine does not effectively extend curcumin’s half-life – offering half-life of only 6 minutes, compared with an impressive half-life of 7 hours with Longvida – the patented delivery system Igennus nutrition scientists selected for our curcumin formulation.