Great for: pregnancy support, heart health, mood and brain function

Pure L-Methylfolate 400µg is a clean-label, hypoallergenic folate supplement formulated by Igennus nutrition scientists to work in harmony with the body. Pure L-Methylfolate delivers an optimal daily dose of 400µg folate in the body-ready and fully methylated form, ideal for providing health benefits without upsetting homeostasis. Each bottle delivers 180 small, easy-to-swallow tablets.


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Certified vegan, non-GMO, hypoallergenic ingredients with no unpleasant additives (no silicon dioxide, magnesium stearate or titanium dioxide). Lab-verified, GMP manufactured in the UK


Expertly formulated to deliver an effective dose of folate in the body-ready and fully methylated form, without overloading the body. Each bottle delivers 180 small 1-a-day tablets


5-methyltetrahydrofolate (5-MTHF) is the metabolically active form of folate, the preferred form for MTHFR gene variants, raising levels 1.8x higher than folic acid


Folate supports mood & brain function, energy, blood formation, homocysteine metabolism & amino acid synthesis. Pregnancy increases folate requirements with low status a risk factor for neural tube defects


Expertly formulated by Igennus nutrition scientists and our resident medical doctor, GMP manufactured in the UK & lab verified to ensure the highest quality
  • Description
  • Contents
  • Directions
  • Warnings
  • Nutrition
  • Allergen information
  • Product guide

L-methylfolate is the fully methylated, body-ready form of folic acid. Supplemental folate intake contributes to normal blood formation (red blood cells) and to the reduction of tiredness and fatigue. During pregnancy, supplementation increases maternal folate status. Low maternal folate status is a risk factor in the development of neural tube defects in the developing foetus. Folate contributes to maternal tissue growth during pregnancy. Folate also has an important contributory role in many other processes, including normal homocysteine metabolism, normal psychological function, the normal function of the immune system and normal amino acid synthesis, and also has a role in the process of cell division.

Each bottle contains 180 tablets, providing a 6-month supply at a daily dose of 1 tablet.

Adults: take 1 tablet daily. Do not exceed the stated dose

This product should not be used as a substitute for a varied and balanced diet and healthy lifestyle. Seek professional medical advice before taking any food supplement if you are pregnant or breastfeeding, or taking medication. Keep out of the reach of children. Store in a cool, dry place and away from sunlight.

Ingredients: Bulking agents: dicalcium phosphate, microcrystalline cellulose; anti-caking agent: ascorbyl palmitate; glazing agent: hydroxypropyl methylcellulose; folic acid (as calcium L-methylfolate).

Folate nutritional panel
folate nutrition table

This product is not made with any ingredients containing gluten, wheat, dairy, soya, eggs, fish, shellfish, tree nuts or peanuts.

Our manufacturing facilities have strict allergen management procedures in place, however we cannot guarantee that our products are made in allergen-free facilities without the very small risk of trace amounts of cross contamination.

Suitable for vegetarians and vegans.

Compatible with halal and kosher diets.

We often get asked many questions about our products, so our nutritionists have compiled this downloadable product information guide to ensure you get the most from taking Pure Folate. Find out when to take it, at what dose and how to maximise absorption for optimum results.


Clean label & hypoallergenic

Pure L-Methylfolate 400µg is a hypoallergenic supplement formulated without any unpleasant additives, including silicon dioxide, magnesium stearate or titanium dioxide. We use only plant cellulose. GMP manufactured in the UK, the ingredients are non-GMO, certified vegan and suitable for those following Halal and Kosher diets.


Optimal dose of bioactive folate

Excessive folate intake can be just as problematic as low folate status. Working in harmony with the body, Pure L-Methylfolate delivers folate in its most active and body-ready form at an optimal daily dose of 400µg to support nutrient status without upsetting homeostasis.



5-MTHF is the biologically active form of folate and unlike the synthetic form of folic acid, bypasses all four enzyme-mediated steps required for activation and use by the body. 5-MTHF, as L-methylfolate, is the preferred form for those with polymorphisms on folate genes (MTHFR).

Active folate for foetal development

Pregnancy support

Pregnancy increases maternal folate requirements and supports maternal tissue growth. Low maternal folate status is a risk factor in the development of neural tube defects in the developing foetus.

Choline for brain health

Heart & homocysteine recycling

High levels of homocysteine have been associated with an increased of poor health outcomes. Homocysteine is a natural by-product of the methylation cycle and requires folate for remethylation to methionine.

folate for mood and brain function

Mood & brain function

Dependent on folate, healthy homocysteine recycling is essential for conversion into proteins involved in sleep and mood regulation and the powerful antioxidant glutathione.

Customer Reviews

Based on 7 reviews
stuart Mayall
Great Product !!!

low on folate... Probably due to digestion and stomach lining issues... I seem to be intollerant (Many unpleasant side effects) to Folic Acid.
These are the best bioactive folate tablets I have tried.. Some of the others have many other ingredients which seem to cause me
problems. No side effects on these and my health certainly seems a little better from using them.

Mood and brain function

I was recommended this product for raising mood and brain function (period of active studying) and I am really pleased with the results! Definetelly would recommend the product. I'm only not sure for how long you can take this on a daily basis so I would have a nutritionist consultation and tests before continuing to take it.

Tee Thom
Raising folate levels without synthetics

I’ve been working to raise my folate levels after blood tests showed a deficiency. The Igennus L-Methylfolate supplements appealed to me as they are an active form of folate so aren’t synthetic, and they don’t include nasty additives. I’m currently suffering from recurring sore throats but these are easy for me to swallow - no pain, and no taste either. I’m hoping when my bloods are retested in the new year, that these supplements will have taken my folate back within an acceptable range. So far, I would definitely recommend.

L Methylfolate

I am not sure how useful L Methylfolate is. This is because I am not sure if the L Methylfolate is beneficial or whether other supplements I am taking are beneficial.

Gillian Lindsay
Unsure of a Positive Effect

I tried these supplements as I had below normal levels of RBC and WBCs. I believe these can help increase red blood cell production? I have just had my bloods retested, so time will tell if they have made a difference or not. I realise that other things in the body can make your blood cell count drop but I was prepared to give these a go. I cant say I feel any different after taking them but would assume they are doing me some good. Easy to take as they are very small.

Be kind to your health

“We are living in a rapidly changing world that challenges us in new and unexpected ways. We believe evidence-based nutrition has an important role to play in helping us to protect and boost our wellbeing. At Igennus we empower people who are committed to investing in their health with high impact nutrition to lead a healthier and fuller life. Our supplements are expertly formulated by our in-house nutrition scientists to achieve superior bioavailability for maximum impact on your health."

Dr Jav Nazemi

CEO & Co-Founder