Neurobalance – Product Spotlight

Zinc PICOLINATE, magnesium citrate & vitamin B6

by nutrition scientist Dr Nina Bailey BSc (Hons), MSc, PhD, RNutr

Neurobalance™ is a unique blend of the most bioavailable forms of zinc, magnesium and vitamin B6, in a sustained-release formula for optimal absorption, which helps to achieve maximum plasma levels and therapeutic benefits throughout the day. This advanced, scientifically formulated supplement offers unique health benefits and is highly synergistic with our omega-3 & 6 oils. In small, easy-to-swallow tablets, they are suitable for adults and children and can be effectively used to support a wide range of common health complaints.  

We introduced Neurobalance to our synergistic nutrients over four years ago to provide a highly advanced nutritional intervention for the management of ADHD, autistic spectrum disorders, dyslexia & dyspraxia, used alone or in combination with our high concentration omega-3 fish oils. Since then, significant research and customer testimonials support the benefits of Neurobalance far beyond neurodevelopmental conditions alone. Today Neurobalance is used by our customers and practitioners to support numerous health issues, from migraine relief and improvements in symptoms of hormonal imbalance, to improved mood, cognitive function and reduced stress and anxiety, as well as to aid sleep quality and recovery from sport and exercise. The multiple health benefits of the combination of highly synergetic nutrients are due to the bioavailable, and therefore effective, forms of the active nutrients used, in combination with our slow-release technology.

What makes Neurobalance™ unique? 

As with all our formulations, Neurobalance provides the most bioavailable and effective nutrient forms, in an optimised delivery system to ensure noticeable benefits.

Magnesium citrate

Nutrient action

Magnesium acts as a co-factor in the regulation of over 300 biochemical processes and is crucial for glucose and fat breakdown, the production of proteins, enzymes and antioxidants such as glutathione, the creation of DNA and RNA, the regulation of cholesterol and ATP production. In addition, magnesium plays a direct role in maintaining normal muscle, healthy bone density and correct nerve function, as well as supporting a healthy immune system. Magnesium is also required for the proper functioning of alkaline phosphatase, the enzyme that facilitates the absorption of vitamin B6.

Ingredient benefits

The citrate form of magnesium is more soluble and therefore more bioavailable than magnesium oxide which is found in many cheaper, less effective supplements.  

Citric acid, the carrier used in our formulation, provides additional health benefits. As a substrate for the Krebs cycle, citric acid contributes to the release of stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats and proteins, resulting in the production of ATP and thus supporting energy levels.  


Nutrient action

Zinc is an essential cofactor for many enzymes active in metabolism and signal transduction and in proteins, such as transcription factors that control gene expression. Zinc also plays an active role in optimising immune health and is essential for healthy skin and hormones.

Ingredient benefits

Zinc picolinate offers superior bioavailability in comparison to the use of zinc citrate and zinc gluconate. (1) As a carrier, picolinic acid offers neuroprotective, immunological and anti-proliferative effects within the body, and may protect from the toxic effects of quinolinic acid. (2)  


Nutrient action

Vitamin B6 is involved in over 100 cellular reactions throughout the body. The pyridoxine form, specifically, is required to metabolise amino acids and glycogen, and for normal nervous system, hormone and red blood cell function. Vitamin B6 is also required for transport and accumulation of magnesium in cells and tissue, making it essential to achieve optimal benefits from magnesium.

Ingredient benefits

Vitamin B6 exists in 6 forms but only the pyridoxal-5-phosphate form has enzyme cofactor activity. Humans have several inborn errors of B6 metabolism, which can compromise the metabolism of dietary vitamin B6 to pyridoxal-5-phosphate, which is required for metabolism of neurotransmitters and other neuroprotective compounds. It is particularly effective in supporting the nervous system.  

Synergistic relationship

Synergistically, these ingredients act to support immune function, improve energy replenishment and reduce fatigue. In addition, vitamin B6 not only improves the uptake of zinc, but is also required for the transport and accumulation of magnesium into cells and tissues. Magnesium, in turn, is required for the proper functioning of alkaline phosphatase, the enzyme that facilitates the absorption of vitamin B6. Thus, there exists a unique and synergistic relationship between these nutrients, making them the ideal trio for optimising numerous areas of health. Neurobalance can be used alone to support the above health conditions and processes, or in combination with our other therapeutic and optimal wellbeing products to provide more comprehensive support.

Who would benefit from Neurobalance?

The key areas of application for Neurobalance are summarised in the table below:

The specific formulation of Neurobalance makes this an advanced choice for supporting central nervous system function and related conditions. The benefits of zinc, magnesium and vitamin B6 combinations (also often referred to as ZMA) are also well recognised in the sports industry where they are linked to increased lean muscular growth and improved recovery after workouts, benefits which are due to zinc’s role in protein synthesis and testosterone production. These three ingredients together also act as antioxidants and immune boosters that help prevent inflammation and cell damage that occurs as a consequence of exercise adaptation. Neurobalance is also highly beneficial in a range of common health concerns, including women’s hormone health, where combined magnesium and vitamin B6 supplementation has been shown to reduce premenstrual anxiety; magnesium, which is often low in migraine sufferers, has been shown to alleviate the frequency and intensity of attacks, and the trio have been related to improved mood and better, more refreshing sleep cycles.

Dosing guide

RI = Reference Intake

Our small, easy to swallow tablets are formulated to allow scaleable and split dosing, which, together with a slow-release delivery system, ensures that Neurobalance delivers tailored, optimal blood plasma levels throughout the day. Easily adaptable for children and adults, Neurobalance is an ideal add-on product for intensive and targeted central nervous system support.  


  1. Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC (1987) ‘Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans.’ Agents Actions, 21(1-2), pp 223-8.
  2. Grant, R. S., Coggan, S. E., & Smythe, G. A. (2009). ‘The physiological action of picolinic acid in the human brain.’ International journal of tryptophan research : IJTR, 2, 71–79.

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