L-Methylfolate 400mcg, Folic Acid 5-MTHF B9 | Igennus

Supplement bottle labeled 'Pure L-Methylfolate' by igennus on a white background

Pure L-Methylfolate 400mcg, Vegan & Clean Label, Methylated Form of Folic Acid 5-MTHF (Vitamin B9), 180 Small Tablets

180 tablets

£17.99

Pure L-Methylfolate 400mcg, Vegan & Clean Label, Methylated Form of Folic Acid 5-MTHF (Vitamin B9), 180 Small Tablets

£17.99

Great for: pregnancy support, heart health, mood and brain function

Pure L-Methylfolate 400µg is a clean-label, hypoallergenic folate supplement formulated by Igennus nutrition scientists to work in harmony with the body. Pure L-Methylfolate delivers an optimal daily dose of 400µg folate in the body-ready and fully methylated form, ideal for providing health benefits without upsetting homeostasis. Each bottle delivers 180 small, easy-to-swallow tablets.

Real use & expert insights

Each bottle contains 180 tablets, providing a 6-month supply at a daily dose of 1 tablet.

Adults: take 1 tablet daily. Do not exceed the stated dose.

This product should not be used as a substitute for a varied and balanced diet and healthy lifestyle. Seek professional medical advice before taking any food supplement if you are pregnant or breastfeeding, or taking medication. Keep out of the reach of children. Store in a cool, dry place and away from sunlight.

Ingredients: Bulking agents: dicalcium phosphate, microcrystalline cellulose; anti-caking agent: ascorbyl palmitate; glazing agent: hydroxypropyl methylcellulose; folic acid (as calcium L-methylfolate).

Nutrient	Per 1 tablet	% NRV*
Folic acid (as calcium L-methylfolate)	400 µg	200

*% Nutrient Reference Value

This product is not made with any ingredients containing gluten, wheat, dairy, soya, eggs, fish, shellfish, tree nuts or peanuts.

Our manufacturing facilities have strict allergen management procedures in place, however we cannot guarantee that our products are made in allergen-free facilities without the very small risk of trace amounts of cross contamination.

Suitable for vegetarians and vegans.

Compatible with halal and kosher diets.

We often get asked many questions about our products, so our nutritionists have compiled this downloadable product information guide to ensure you get the most from taking Pure Folate. Find out when to take it, at what dose and how to maximise absorption for optimum results.

L-methylfolate is the biologically active form of folate and demonstrates superior bioavailability compared to folic acid:

Bayes, J. et al. The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review. J Altern Complement Med. 2018 Jul 16
Obeid, R. et al. Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts. Nutrients. 2020 Nov 25;12(12):3623
Pietrzik, K. et al. Folic acid and L-5 methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48

Folic acid supplementation can lead to circulating unmetabolised folic acid (UMFA), whereas L-methylfolate bypasses this metabolic step:

Palchetti, C.Z. et al. Association between Serum Unmetabolized Folic Acid Concentrations and Folic Acid from Fortified Foods. J Am Coll Nutr. 2017 Sep-Oct;36(7):572-578
Patanwala, I. et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014 Aug;100(2):593-9
Troen, A.M. et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr. 2006;136:189–194

L-methylfolate bypasses common MTHFR polymorphisms that can impair folic acid metabolism:

Liew, S.C. and Gupta, E.D. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. Eur J Med Genet. 2015 Jan;58(1):1-10
Prinz-Langenohl, R. et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009 Nov 16;158(8):2014–2021
Vidmar Golja, M. Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate. J Clin Med. 2020 Sep 2;9(9):2836

PURE & CLEAN -

we use hypoallergenic and lab-verified ingredients with no unnecessary additives; UK GMP-manufactured, certified vegan, non-GMO & compatible with halal and kosher diets

OPTIMAL DAILY DOSE -

expertly formulated to deliver an effective dose of folate in the body-ready and fully methylated form, without overloading the body. Each bottle delivers 180 small 1-a-day tablets

BIOACTIVE FORM -

5-methyltetrahydrofolate (5-MTHF) is the metabolically active form of folate, the preferred form for MTHFR gene variants, raising levels 1.8x higher than folic acid

PREGNANCY, HEART & MOOD SUPPORT -

folate supports mood & brain function, energy, blood formation, homocysteine metabolism & amino acid synthesis. Pregnancy increases folate requirements with low status a risk factor for neural tube defects

SUPPLEMENTS YOU CAN TRUST -

expertly formulated by Igennus nutrition scientists and our resident medical doctor, GMP manufactured in the UK & lab verified to ensure the highest quality

Two bottles of Pure L-Methylfolate with tablets and vegetables on a white background.

Two bottles of Pure L-Methylfolate with text highlighting ease of swallowing and purity on a light background with vegetables.

Infographic about L-Methylfolate with text and icons on a green background

Infographic about L-Methylfolate with text and icons on a white background

Close-up of green leaves with water droplets

Bioavailable form

Pure L-Methylfolate (as Calcium L-MTHF) is the fully methylated, highly absorbable and body-ready form of folic acid, offering 200x greater bioavailability and 1.8x higher blood levels than standard folic acid. L-Methylfolate is an ideal form for individuals with MTHFR gene polymorphisms, as folate levels increase in the body irrespective of genotypes.

Assorted beans and legumes in burlap bags

Clean label & hypoallergenic

Pure L-Methylfolate 400mcg is a hypoallergenic supplement formulated without any unnecessary additives, such as silicon dioxide, magnesium stearate or titanium dioxide. We use only plant cellulose. GMP manufactured in the UK, the ingredients are non-GMO, certified vegan and suitable for those following Halal and Kosher diets.

Optimum dose, small tablets

A daily dose of 400mcg provides an optimal 200% of the Nutrient Reference Value. Formulated to ensure that the dose is not excessive, to avoid symptoms such as nausea, therefore is suitable for long-term use. Delivered in small, easy-to-swallow tablets. Taken at the recommended dose of 1 tablet daily, each bottle provides 180 servings.

Pregnant woman in a blue shirt and gray pants sitting on a white couch.

Foetal tissue growth during pregnancy

Folate plays an important role in cell division, including normal maternal tissue growth during pregnancy. As low folate status is a risk factor in the development of neural tube defects, taking a folate supplement is ideal for women of childbearing age or for those planning to conceive. Folate is particularly important to take prior to conception and until the twelfth week of pregnancy.

Senior couple embracing in a field with a scenic background

Energy levels

Folate supplementation may help to reduce tiredness and fatigue. As folate is necessary for proliferation of cells, low folate status can negatively affect the production of red blood cells. This may result in anaemia due to insufficient numbers of red blood cells which are required for oxygen transfer. The reduced oxygen-carrying capacity of the blood leads to symptoms of weakness, fatigue, irritability, and shortness of breath.

Healthy homocysteine levels

Folate is essential for normal homocysteine metabolism in the body. Homocysteine is a natural by-product of the methylation cycle usually converted into essential proteins involved in normal processes such as sleep and mood regulation, or the powerful antioxidant glutathione. Low folate status and the resulting accumulation of homocysteine may increase the risk of cardiovascular disease and cognitive dysfunction.